cobra:bio

As a leading manufacturer of Biopharmaceuticals, Cobra Biomanufacturing is dedicated to designing robust processes for its international life science customers that deliver quality commercial, clinical, and pre-clinical products. To comply with the rigorous regulatory requirements of today our flexible and resourceful teams devise innovative, streamlined and optimised solutions to overcome the hurdles in manufacturing proteins, viruses, DNA, and cell products. All our programs meet cGMP standards worldwide with full regulatory support.

A vacancy has arisen in the Molecular Biology group at Cobra Biomanufacturing Plc for a microbial molecular geneticist. The ideal candidate will possess an M.Sc. or Ph.D. in the biological or biomedical sciences, and be skilled in the construction of plasmids for gene expression and genetic modification of bacteria. The candidate will be required to work on a number of projects in the following areas:

• Construction and evaluation of oral malaria and tuberculosis vaccines. An EU Sixth Framework-funded grant with an international consortium, in which Cobra is focussing on genetically fusing antigens to the spore coat of Bacillus subtilis for vaccine delivery. The programme has the potential to develop stable vaccines that can be stored at room temperature and administered orally. This will be the primary role of the successful candidate in 2010.
   
• Bacterial vectors for oral delivery of HIV, influenza and tuberculosis vaccines. A Technology Programme-funded consortium, coordinated by Cobra, to genetically engineer attenuated Salmonella to deliver protein and DNA vaccines orally to stimulate the mucosal immune system via the lining of the gastrointestinal tract, using Cobra’s ‘ORT-VAC’ technology.
   
• Optimisation of expression systems. Cobra has a number of proprietary genetic technologies for commercial production of biopharmaceuticals for clients ranging from the largest international pharmaceutical to start-up biotechnology companies. The role will also involve designing and constructing expression plasmids and strains to improve our technology for the benefit of our clients.

Applications should be sent in writing stating the appropriate reference number with full C.V. and current salary details to: Marie Cooper, HR Administrator, Cobra Biomanufacturing Plc or email; marie.cooper@cobrabio.com

As a leading manufacturer of Biopharmaceuticals, Cobra Biomanufacturing is dedicated to designing robust processes for its international life science customers that deliver quality commercial, clinical, and pre-clinical products. To comply with the rigorous regulatory requirements of today our flexible and resourceful teams devise innovative, streamlined and optimised solutions to overcome the hurdles in manufacturing antibodies, proteins, viruses, DNA, and cell products. All our programs meet cGMP standards worldwide with full regulatory support.

A vacancy has arisen for a Process Development Scientist within the Operations Group.

Main duties will include:

• To contribute to the planning of process development and technology transfer projects by providing estimates for required resources and schedules.
• To execute and complete assigned process development / technology transfer experimental work both in house and contractually in a timely manner.
• To interpret data and communicate results. To make judgements on the impact of the data and relevance to the process development.
• To form part of multidisciplinary teams working within all areas of the Operations Group.

The ideal applicant will have practical experience in mammalian and/or microbial cell culture techniques, cell growth and sound knowledge of fermentation principles is desirable. Awareness of scale up and GMP procedures would also be a distinct advantage.

Candidates must be flexible in their approach to work and willing to work additional hours to accommodate processing. The enthusiasm to learn and the ability to interact and communicate effectively with colleagues at all levels within the organisation are also essential.

The ideal applicant will possess a degree in Biochemistry, Biotechnology Engineering or equivalent qualification or newly qualified post doctoral qualification and / or previous practical laboratory experience in a relevant technical area in an academic or industrial environment. Able to demonstrate strong written and verbal communication skills and able to demonstrate strong practical skills within their area of expertise.

Applications should be sent in writing stating the appropriate reference number with full C.V. and current salary details to: Marie Cooper, HR Administrator, Cobra Biomanufacturing Plc or email; marie.cooper@cobrabio.com

As a leading manufacturer of Biopharmaceuticals, Cobra Biomanufacturing is dedicated to designing robust processes for its international life science customers that deliver quality commercial, clinical, and pre-clinical products. To comply with the rigorous regulatory requirements of today our flexible and resourceful teams devise innovative, streamlined and optimised solutions to overcome the hurdles in manufacturing proteins, viruses, DNA, and cell products. All our programs meet cGMP standards worldwide with full regulatory support.

Cobra is offering exciting opportunities for highly motivated Production Scientist(s) to join the Operations group at its Keele facility.

Main duties will include:

• Participate in multi-disciplinary teams to carry out assigned operations and procedures according to a project plan
• Ensure Batch manufacturing Records are completed and maintained according to Cobra Standard Operating Procedures
• Provide results, data and progress to project leaders
• Work as part of the internal project teams
• Train less experienced staff in techniques, as required

The ideal applicant will possess a minimum Btech/NVQ or BSc in a Science subject or equivalent qualifications plus previous experience in a scientific GMP laboratory environment. In addition, the successful candidates will have a strong working knowledge of bacterial fermentation / mammalian fermentation. Previous practical experience in mammalian or bacterial cell culture, fermentation, column chromatography, filtration and down-stream purification technologies within an industrial environment is desirable.

Applicants will be expected to work as part of a team, have excellent communication skills (verbal/written), strong organisational skills and show a high degree of motivation for the manufacture of tomorrow’s medicines.

Applications should be sent in writing stating the appropriate reference number with full C.V. and current salary details to: Marie Cooper, HR Administrator, Cobra Biomanufacturing Plc or email; marie.cooper@cobrabio.com

As a leading manufacturer of Biopharmaceuticals, Cobra Biomanufacturing is dedicated to designing robust processes for its international life science customers that deliver quality, clinical, and pre-clinical products. To comply with the rigorous regulatory requirements of today our flexible and resourceful teams devise innovative, streamlined and optimised solutions to overcome the hurdles in manufacturing proteins, viruses, DNA, and cell products. All our programmes meet cGMP standards worldwide with full regulatory support.

A vacancy has arisen for a Section Head of Quality Assurance within the Quality Department, Keele, reporting to the Corporate Director of Quality.

Main duties will include:

• Working within the Corporate QA Division, managing various aspects of the quality system associated with the Keele facility to maintain compliance with current corporate, regulatory and industry best practice guidelines.
• Managing and developing staff within the Quality department through the performance management system.
• Recruit staff as required to meet contract needs.
• Working in close co-operation with process scientists, production staff, commercial staff, clients and regulatory bodies to assure quality and to deliver successful projects for our clients.
• Deputise for and assist the Corporate Director of Quality when required.

Undertake routine QA support activities to support client contracts.

This is a high profile role within the company, and whilst the role is primarily based at the Keele facility, the person appointed will be expected to take a proactive leadership role in quality across the company.

The ideal applicant will possess a degree in Chemistry, Biology, Pharmacy or equivalent qualifications together with extensive experience in quality assurance and staff management. 

Applications should be sent in writing stating the appropriate reference number with full C.V. and current salary details to: Marie Cooper, HR Administrator, Cobra Biomanufacturing Plc, or email; marie.cooper@cobrabio.com