Development of robust and scaleable manufacturing processes
Media development and optimisation (animal component free)
Optimisation of harvest parameters to improve both quality and productivity
Development of efficient extraction and primary recovery procedures (including inclusion body purification)
Chromatographic purification
Purification by low pressure chromatography
Formulation development
Fermentation & media development
Evaluation of productivity and optimisation of harvest point
Lysis optimisation (primary recovery)
Non-animal derived components
Proprietary technology:
- DNA process (Type II Drug Master File (DMF) with US FDA)
Production for pre-clinical efficacy testing and pivotal preclinical safety testing
Optimisation of multiplicity and point of infection (MOI & POI)
Sterile harvest & cell washing facilities