Phage Development & Manufacturing

Cobra has experience with cell lines:

  • E.coli
  • S.aureus

Plus the following phage types:

  • Filamentous
  • Lamda
  • Lytic / non-lytic
  • Native / engineered

With production up to 50L scale in a fermentation system, plus chromatographic purification, Cobra provides process development and scale up of customers’ phage products including:

  • Master Virus Seed Stock (MVSS) production by plaque purification
  • Upstream processing optimisation including Multiplicity and Point of Infection (MOI / POI) optimisation
  • Point of Harvest (POH) optimisation
  • Fermentation development
  • Product delivery
  • Chromatographic purification for the removal of host contaminants
  • Formulation 

Cobra manufactures to cGMP standards for pre-clinical to clinical and commercial scale, providing Quality Assurance and regulatory support.
Our expert team also offers analytical development and qualification including:

  • Assay development and transfer
  • Product Characterisation
  • QC Release Testing
  • QC testing: Drug Substance and Drug Product
  • Cell based potency assays
  • Stability Studies to ICH guidelines: Drug Substance & Drug Product (forced degradation & pre-formulation studies)
  • Cleaning validation
  • Raw material testing

For more information, get in touch with our expert team today.

Other Viral Vectors Services...

In order to provide complete functionality, this web site needs your explicit consent to store browser cookies. If you don't allow cookies, you may not be able to use certain features of the web site. It is recommended that you allow all cookies. Allow all cookies