Experts in whole cell microbiota vaccine development

• Development of fully closed systems; sterile processes for whole cell parenteral products
• Traditional stainless steel systems for oral products
• Development of robust and scalable manufacturing processes
• Media development and optimisation (animal component free)
• Optimisation of harvest parameters to improve both quality and productivity
• Formulation
• Development of sterile harvest concentration & cell washing systems

• Analytical method transfer, development, qualification & validation
• Analytical methods include: Identity by microbiological characterisation of the strain, purity (monosepsis), strength by determination of viability, development of cell based potency assays

Cobra provides expert contract manufacturing of whole cell microbiota vaccines in compliance with GMP standards.

• Master Cell Bank & Working Cell Bank production
• Pre-clinical and clinical supply
• Aerobic and anaerobic cell capability